No needle, intravenous tubing or any other device for parenteral administration should be attached to the oral syringe.
#SECRETS OF THE LOST TOMB EXPANSIONS HOW TO#
If it is particularly difficult to get the syringe into the buccal cavity, then administer the whole dose, over a period of 4-5 seconds, to one buccal cavity.įor instructions on how to administer the medicinal product before administration see below.ĭo not use if the solution is not clear (e.g. Laryngo-tracheal insertion should be avoided to prevent accidental aspiration of the solution. Using the pre-filled oral syringe provided, administer, over a period of 2-3 seconds, approximately half of the prescribed dose to each buccal cavity (space between the gum and the cheek). The amber sheath cap should be removed before use. No efficacy studies of midazolam in children with cardiac insufficiency have been reported. No efficacy studies of midazolam in critically ill children have been reported. Therefore, the clinical effects may be stronger and prolonged, hence careful monitoring of the clinical effects and vital signs is recommended following administration of midazolam in patients with hepatic impairment (see section 4.4).Įpistatus is contraindicated in patients with severe hepatic impairment (see section 4.3). Hepatic impairment reduces the clearance of midazolam with a subsequent increase in terminal half-life.
No efficacy studies of midazolam in children with chronic hepatic impairment have been reported. However, in the setting of treatment of an acute epileptic seizure with a single or 2 doses of midazolam, accumulation of parent drug or metabolite is unlikely to occur causing prolongation of clinically significant pharmacological effects. Multiple doses of midazolam in patients with chronic renal failure may result in delayed elimination of midazolam and prolongation of effects. No efficacy studies of midazolam in children with chronic renal failure have been reported. No efficacy studies of midazolam in obese children have been reported. This medicine should only be given to children and adolescents aged 10 years to less than 18 years.
#SECRETS OF THE LOST TOMB EXPANSIONS PROFESSIONAL#
The empty syringe must be given to the healthcare professional to provide information on the dose and product received by the patient.Īfter receiving midazolam, patients should be kept under supervision by a carer who remains with the patient.Ī second or repeat dose when seizures re-occur after an initial response should not be given without prior medical advice (see section 5.2). If the seizure does not stop shortly after administration of midazolam, emergency medical assistance must be sought, taking into account prior instructions from the prescribing physician, or local guidelines. Date of first authorisation/renewal of the authorisationĬhildren and adolescents aged 10 to less than 18 years of ageĬarers should only administer a single dose of midazolam.
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